PBA光纤化学传感器在线监测家兔口服呋喃妥因的尿药浓度  

The PBA Fiber Optical Chemical Sensor for On-line Measurement of Nitrofurantoin in Urine

作　　者：陈坚[1] 朱滨[1] 

机构地区：[1]新疆医学院药学系

出　　处：《分析科学学报》1994年第4期31-35,共5页Journal of Analytical Science

基　　金：国家卫生部资助

摘　　要：芘丁酸光纤化学传感器（ＰＢＡ—ＦＯＣＳ）用于在线测定家兔口服呋喃妥因后排出尿液中的药物浓度。方法的检出限为１．３μｇ／ｍＬ，线性范围１～１００μｇ／ｍＬ，精密度（ＲＳＤ）１．５～３．５％，回收率在９５．０～１００％之间。４只雄性家兔的尿药浓度—时间曲线显示达峰时间为３．５ｈ，６ｈ累积尿药排出百分率为２１％。实验结果显示传感器、测定池和仪器系统设计合理。可实时、在线测定生物体液中的药物浓度并达到实用水平。In this paper, the PBA fiber optical chemical sensor for measurement of aromatic nitro pharmaceutics based on fluorecence quenching was developed. It was used for on line measurement of nitrofurantoin in rabbits urine. The limit of detection was 1. 3μg/mL. The linear range of calibration curves are 1 100μg/mL with r> 0. 999 and RSD=1. 5 3. 5 %. The average recoveries were 95. 5 % 100 %. The test results showed that PBA-FOCS, uric drug cell and apparatus system are stability, sensitivity and arrived practical requirement.

关 键 词：芘丁酸 光纤化学传感器 呋喃妥因 尿药浓度 

分 类 号：R927.1[医药卫生—药学]