人参三醇组甙对雄性大鼠阿片肽与免疫功能的辐射防护作用  

RADIOPROTECTIVE EFFECTS OF PANAXATROIL ON OPIOID PEPTIDES AND IMMUNE FUNCTIONS IN MALE RATS

作　　者：刘伟宏[1] 龚守良[1] 李修义[1] 李新民[1] 刘树铮[1] 

机构地区：[1]白求恩医科大学放射生物教研室

出　　处：《辐射研究与辐射工艺学报》1994年第3期169-173,共5页Journal of Radiation Research and Radiation Processing

摘　　要：采用５ＧｙＸ射线全身照射雄性大鼠模型，大鼠于照射前２４ｈ及照射后，每天腹腔注射５ｍｇ／０．２ｍｌ人参三醇组甙，共注射１４ｄ，观察人参三醇组甙对其阿片肽与免疫功能的辐射防护作用。结果表明，照射组下丘脑阿片肽含量及胸腺和脾脏免疫参数均降低；而在照射加人参组下丘脑阿片肽组水平，所有的免疫参数虽降低但却高于照射组。结果提示，人参三醇组甙可减轻下丘脑网片肽含量及含量接近对照胸腺和脾脏免疫参数的降低，具有辐射防护作用。The present study was designed by ip panaxatroil(5mg/0.2 ml'd x14 d) 24 h before and arter 5 Gy whole--body X-irradiation in male rats to observe the radioprotective effects of panaxatroil on opioid peptides and immune functions. The results showed that the hypothalamic opioid peptide contents and the immune parameters of thymus and spleen cells all decreased 14 d after irradiation, while hypothamamic opioid peptide contents approached the control level and all immune parameters decreased in irradiation plus panaxatroil group but higher than that in control group. The above results suggest that panaxatroil may alleviate the decrcase of hypothamamic opioid peptide contents and immune parameters of thymus and spleen cells, and have radioprotective effects.

关 键 词：人参三醇组甙 辐射防护 阿片肽 

分 类 号：R811.5[医药卫生—放射医学]