肝部分切除术后门静脉和肝动脉血中PGI_2及TXA_2的含量变化  

Changes of PGI_2 and TXA_2 levels in patients hepatic artery and portal veins after partial hepatectomy

作　　者：施乐华[1] 吴孟超[1] 陈汉[1] 黄兴耀[1] 王墨荣[1] 

机构地区：[1]第二军医大学肝胆外科研究所,江苏启东肝癌防治研究所

出　　处：《肝胆外科杂志》1994年第2期114-116,共3页Journal of Hepatobiliary Surgery

摘　　要：为了解前列环素（ＰＧＩ２）、血栓素（ＴＸＡ２）与肝部分切除术（ＰＨ）后肝功能恢复的关系．本文用放射免疫测定法测定了３２例肝部分切除患者肝动脉、门静脉血中ＰＧＩ２及ＴＸＡ２的稳定代谢产物６－ＫｅｔｏＰＧＦ１ａ和ＴＸＢ２的含量．结果表明．肝功能正常情况下ＴＸＡ２／ＰＧＩ２保持一定比值；肝硬化时ＰＧＩ２及ＴＸＡ２出现代谢障碍，平衡趋向于ＰＧＩ２占优势．ＰＨ后．此状况更明显．从而提示：（１）ＰＧＩ２可能与肝功能储备有关．ＴＸＡ２／ＰＧＩ２值与术后肝功能恢复有关；（２）测定围手术期的ＴＸＡ２和ＰＧＩ２可作为判断术后预后的指标；（３）保持ＴＸＡ２／ＰＧＩ２值的相对稳定．可望改善ＰＨ患者的预后。In order to investigate the relationship between TXA2 and PGI2 with liver function recovery after perilal hepetectomy,hepatic arterial and portal venous concentration of TXB2 and 6-Keto-PGF1a, which are stsble metabolites of PGI2 and TXA2 were measured by radioimmunoassay in 32 partial hepatomized patients.The results showed that TXA2/PGI2 ratio was kept constant in normal physiological condition but become low in cirrhotic patient and more significant during partial hepatectomy. It is concluded that keeping TXA2/PGI2 ratio constant could improve prognosis of patients after hepatectomy.

关 键 词：肝切除 前列环素 血栓素 

分 类 号：R657.305[医药卫生—外科学]