雷公藤单体对SLE患者淋巴细胞体外分泌IgG和抗双链DNA抗体的影响（二）  

Effects of Monomer of Tripterygium Wilfordii Hook on IgG and Anti-dsDNA Secretion of Lymphocyte from Patient with SLE in vitro

作　　者：夏金华[1] 吴厚生[1] 秦万章[1] 

机构地区：[1]上海医科大学免疫学教研室,上海医科大学附属中山医院

出　　处：《赣南医学院学报》1994年第1期12-14,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：本文用ＤＮＡ抗原诱导ＳＬＥ患者的ＰＢＭＣ分泌抗ｄｓＤＮＡ抗体的模型，研究了中药雷公藤治疗ＳＬＥ的作用机理，发现雷公藤单体能强烈地抑制患者细胞分泌特异性（ａｎｔｉ－ｄｓＤＮＡ）和非特异性抗体（ＩｇＧ），且大于甲基强的松龙的抑制效果。The mechanism of SLE treated by traditional chinese medicine-Tripterygium Wilfordii Hook(TWH)has been studied by using the model that DNA antigen induce SLE PBMC to secret anti-dsDNA antibody.It's shown that the monomers of TWH could strongly inhibite the lymphocyte from SLE patients secreting specific(anti-dsDNA)and nonspecific(IgG)antibodies and their inhibition effects are more than Methylprednisolone.

关 键 词：雷公藤 药理学 系统性 红斑狼疮 

分 类 号：R282.710.5[医药卫生—中药学]