放射增敏性导弹型卟啉的合成与性质研究  

The Synthesis and Characteristics of Missile Type Porphyrin with Radio Sensitization

作　　者：刘玉文[1] 徐坚平 王杏乔[1] 曹锡章 李光[1] 高汝贵[1] 

机构地区：[1]吉林大学化学系,中国医科大学附属一院放射肿瘤科

出　　处：《高等学校化学学报》1994年第1期5-8,共4页Chemical Journal of Chinese Universities

基　　金：南京大学配位化学研究所国家重点实验室资助

摘　　要：用化学方法成功地将放射增敏剂灭滴灵连接到对癌细胞具有定位作用的原卟啉上，通过红外光谱、紫外可见吸收光谱、质谱、核磁共振谱和元素分析等手段确证了其结构。经动物实验证明，放射增敏效果较好。The metronidazole as a radio-sensitizer was chemically combined with protoporphyrin which has shown some orientating effects on cancer cells.The structure of this new compound was confirmed by the UV,IR spectra and elementary analysis.It is found that the porphyrin has shown some potential drug effect in aminal test and the decrease of dosage and reduction of toxicity.

关 键 词：放射增敏 卟啉 抗癌药 甲硝羟乙唑 

分 类 号：R979.19[医药卫生—药品]