头孢噻肟钠的降解及其产物伏安行为的研究  

Studies on the Degradation of Cefotaxime and Voltammetric Behaviour of Degradation Product

作　　者：李启隆[1] 陈寿爱[1] 尚军[1] 

机构地区：[1]北京师范大学化学系

出　　处：《高等学校化学学报》1994年第3期339-342,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：头孢噻肟钠在ＮａＯＨ溶液中降解后，于０．１ｍｏｌ／ＬＮａＯＨ中得一灵敏的吸附伏安还原峰，Ｅ＿ｐ＝－０．７８Ｖ（ｖｓ，Ａｇ／ＡｇＣｌ），ｉ＿ｐ与头孢噻肟钠浓度在１．０×１０￣（－９）～１．０×１０￣（－８）、１．０×１０￣（－８）～１．０×１０￣（－７）、１．０×１０￣（－７）～１．０×１０￣（－６）ｍｏｌ／Ｌ范围内呈线性关系，检出限为５．０×１０￣（－１０）ｍｏｌ／Ｌ，用多种电化学手段研究其降解产物的伏安行为，测定了电极反应的有关参数，探讨了降解反应和电极反应机理。实验表明，体系属准可逆吸附波。The degradation of cefotaxime was carried out in NaOH solution at 100℃ for 20min. A sensitive reduction peak of degradation product was obtained by adsorptive stripping voltammetry in 0. 1 mol/L NaOH, at accumulation time of 60 s. Ep=-0. 78 V (vs. Ag/AgCl). ip is directly proportional to the concentration of cefotaxime over the range from 1. 0×10￣(-9) to 1. 0×10￣(-6) mol/L, with a detection limit of 5. 0×10￣(-10) mol/L. The voltammetric behaviour of degradation product has been studied. The parameters of electrode reaction have been determined. The mechanisms about the degradation and electrode reactions were discussed.

关 键 词：头孢噻肟钠 降解 吸附溶出伏安法 

分 类 号：TQ460.72[医药卫生—药物分析学]