不对称环磷化合物的合成及立体化学（Ⅰ）──环磷酰氯和3－羟基异噁唑的反应及其立体化学  

Synthesis and Stereochemistry of 4-Substitutedphenyl-1,3,2-dioxaphosphorin Compounds(Ⅰ)──Reaction and Stereochemistry of Cyclic Phosphorochloridates and 3-Hydroxyisoxazole

作　　者：邵瑞链[1] 杨敏华[1] 职承信 

机构地区：[1]天津南开大学元素有机化学研究所

出　　处：《高等学校化学学报》1994年第10期1473-1476,共4页Chemical Journal of Chinese Universities

摘　　要：研究了２－氧代－２－氯－４－取代苯基－５，５－二甲基－１，３，２－二氧磷杂环己烷与３－羟基异　唑的反应，得到的氧磷酰化产物含有顺反两种异构体，用￣１ＨＮＭＲ、￣（３１）ＰＮＭＲ、Ｘ射线衍射确定了它们的构型，并讨论了亲核取代反应中手性磷原子构型保持和翻转的机理，测定了异构体的生物活性。Owing to the biological activities of 3-hydroxyisoxazole and cyclic phosphate derivatives,some compounds possessing the two moieties were synthesized,the structural elucidation of these diastereomers was made depending on spectral analyses.The mechanism could be illustrated by the theories of trigonal bipyramide intermediate and pseudorotation.

关 键 词：环磷酰氯 羟基异恶唑 立体化学 

分 类 号：O627.51[理学—有机化学]