三菲咯啉合铁手性配合物键合DNA的立体选择性  

Stereoselectivity in Chiral Complex Tris(phenanthroline) Iron (Ⅱ)Binding to DNA

作　　者：杨频[1] 靳兰[1] 杨斌盛[1] 

机构地区：[1]山西大学分子科学研究所

出　　处：《高等学校化学学报》1994年第12期1742-1745,共4页Chemical Journal of Chinese Universities

摘　　要：应用光谱法研究了手性金属配合物［Ｆｅ（ｐｈｅｎ）＿３］￣（２＋）与小牛胸腺ＤＮＡ的作用，确定了△型异构体对Ｂ型右手螺旋ＤＮＡ有优先键合的立体选择性．The chiral complexes tris (phenanthroline) iron (Ⅱ) were synthesized. The structures of the complexes were determined by IR, UV, EXAFS, CD. The binding of the complexes to calf thymus DNA was studied by spectral methods. Hypochromism and enhancement of luminescence accompany DNA binding and the binding show the characteristic of intercalation. The enhancement of luminescence seen for △ isomer in the presence of DNA is greater than that for ∧ isomer. The luminescence quenchng produced by [Fe(CN)_6]￣(4-) for △ isomer in the presence of DNA is smaller than that for A isomer. It means that △isomer binds preferentially to B-DNA.

关 键 词：铁络合物 DNA 立体选择性 

分 类 号：O641.4[理学—物理化学]