三硝基甲苯对大鼠睾丸某些生化功能的影响  

CHANGES OF CERTAIN BIOCHEMICAL FUNCTION IN RATS EXPOSED ACUTELY TO TRINITROTOLUENE

作　　者：常元勋[1] 崔京伟[1] 杨润宽[1] 周威 赵春艳[1] 田瑞泉[1] 江泉观[1] 

机构地区：[1]北京医科大学劳动卫生教研室

出　　处：《工业卫生与职业病》1994年第1期15-18,共4页Industrial Health and Occupational Diseases

摘　　要：本研究采用急性染毒方式，观察三硝基甲苯（ＴＮＴ）对大鼠睾丸某些生化功能的影响。结果表明，２０００ｍｇ／ｋｇＴＮＴ染毒组睾丸葡萄糖－６－磷酸脱氢酶（Ｇ－６－ＰＤ）、乳酸脱氢酶（ＬＤＨ）、山梨醇脱氢酶（ＳＤＨ）和酸性磷酸酶（ＡＣＰ）活性下降，睾丸锌含量下降，而血清锌含量上升。１０００ｍｇ／ｋｇＴＮＴ染毒组睾丸Ｇ－６－ＰＤ和ＡＣＰ活性也下降，而血清锌含量升高。表明睾丸中Ｇ－６－ＰＤ和ＡＣＰ活性以及血清锌含量变化较为敏感。The changes of certain biochemical functions in rats exposed acutely toTNT were investigated. The results showed that the activities of G-6-PD ,LDH, SDH and ACP of rat testes were lower than those of controls at dose of 2000mg/kg TNT. The testicular zinc contents were lower, while serum zinc contents were higher than those of controls at dose of 2000mg/kg TNT. At dose of 1000mg/kg TNT, the activities of G-6-PD and ACP of rat testes were decreased too, while the serum zinc contents still increased. This study indicated that the changes of the activities of G-6-PD and ACP of rat testesand the contents of serum zinc were more sensitive to TNT toxicity.

关 键 词：睾丸 梯恩梯 生化功能 

分 类 号：R598.02[医药卫生—内科学]