胸液腺苷脱氨酶与T淋巴细胞亚群关系  

ADENOSINE DEAMINASE AND T-LYMPHOCYTE SUBSETS IN PLEURAL FLUID

作　　者：陈飞鹏[1] 周太原[1] 潘巧红[1] 胡惠娟[1] 许建邦[1] 

机构地区：[1]广州医学院第二附属医院内科

出　　处：《广东医学》1994年第3期153-154,共2页Guangdong Medical Journal

摘　　要：不少学者已经证实结核性胸液的腺苷脱氨酶(ADA)升高,检测胸液ADA对结核性与非结核性胸液的鉴别有较大的实用价值。然而,ADA在结核性胸液中增高的原因还不清楚,有人认为可能与胸液T细胞亚群有关。我们对1991年2月～1992年3月期间住院的48例胸腔积液患者进行胸液ADA和T细胞亚群检测,探讨二者的关系。 材料和方法 一、检测对象 1.结核性胸腔积液16例,其中男性11例,女性5例。平均38岁(18～77岁)。临床表现、X线及胸液实验室检查符合结核性胸膜炎,抗结核治疗效果好。 2.癌性胸腔积液19例,其中男性9例,女性10例。平均54岁(24～68岁)。包括支气管癌15例,肺转移癌4例。 3.其它病因的胸腔积液13例,其中男性9例,女性4例,平均66岁(32～81岁)。包括肺炎2例,肝硬化1例,心力衰竭6例,甲状腺功能低下1例。The ADA and T - lymphocyte subsets in pleural fluid were determined in 16 cases of tuberculous pleuritis, 19 cases of malignant pleura! effusion and 13 cases of other origins.The results showed that ADA activity in pleural fluid was significantly higher in tuberculous group than in malignant group or other origins group,The percentage of CD3+T cells in pleural fluid did not show any statistically significant differences between tuberculous group and malignant group but was slightly higher in tuberculous group than in other origins group .The percentages of CD4 + and CD8+T cells and CD4 + /CD8+Tcells ratio in pleural fluid did not show any statistically significant differences between tuberculous group .malignant group and other origins group,AD A activity was not correlative with the percentages of CD4 + and CD8+T cells and CD4 + /CD8+T cells ratio in the pleural fluid. The results suggest that increase of ADA activity in tuberculous pleural fluid may be due to the proliferation of T-lymphocytes in tuberculous pleuritis lesion and the increase of ADA released from the pleural T - lymphocytes into pleura] fluid.

关 键 词：胸液 腺苷脱氨酶 淋巴细胞 

分 类 号：R561.03[医药卫生—呼吸系统]