重力变化对小鼠神经内分泌及免疫功能的影响  

Effects of Gravity Changes on Neuroendocrine and Immune Functions in Mice

作　　者：温秀兰[1] 钱锦康[1] 王宝珍[1] 杨光华[1] 汪涛[1] 

机构地区：[1]北京航天医学工程研究所

出　　处：《航天医学与医学工程》1994年第4期273-278,共6页Space Medicine & Medical Engineering

摘　　要：为研究航天特殊环境对机体神经内分泌免疫功能的影响，探讨了超重与模拟失重对小鼠脑递质去甲肾上腺素（ＮＡ）、多巴胺（ＤＡ）、五羟色胺（５～ＨＴ）、血浆皮质酮及淋巴细胞转化的影响。结果表明，３级起飞曲线峰值５Ｇ加速度（约８００Ｇｓ）作用后即刻ＮＡ、ＤＡ升高，皮质酮和Ｔ细胞转化增加，Ｂ细胞转化显著降低，作用后７２小时ＮＡ、ＤＡ、皮质酮恢复，Ｔ、Ｂ细胞转化明显升高，５－ＨＴ升高，作用后１４４小时ＮＡ、ＤＡ、５－ＨＴ均恢复正常组水平，皮质酮则明显降低，Ｔ、Ｂ细胞转化开始恢复，但仍高于正常对照组水平。模拟失重等因素作用１２ｄ，小鼠脑ＮＡ、ＤＡ升高，５－ＨＴ无变化，皮质酮明显升高，Ｔ、Ｂ细胞转化明显降低。Effects of hypergravity and simulated weightlessness on brain transmitters (NA , DA,5-HT).Plasma corticosterone and lymphoblastic transformation were ob-served in mice. It was demonstrated that the levels of norepinephrine ,dopamine , plasmacorticosterone and the transformation of T cell were all markedly increased , but the trans-formation of B cell was decreased immediately after+5G acceleration(800Gs).72hours after the stimulus the level of norepinephrine dopamine ,plasma corticosterone,were all restored , the transformation of T cell and B cell were all increased,the level of5-hydroxytryptamine (5-HT)was higher than that in the control.144 hours after thestimulus, norepinephrine, dopamine and 5-HT were all restored to the level of controlgroup , the plasma corticosterone was markedly decreased , the transformations of T celland B cell were all restored,but were higher than that in the control.12 days after simu-lated weightlessness ,the content of norepinephrine and dopamine in the brain were higherthan that of control group ,the 5-HT did not change ,plasma corticosterone was signifi-cantly higher than that in the control group.The transformations of T cell and B cellwere all significantly decreased as compared with the control group.

关 键 词：超重 模拟失重 皮质酮 淋巴细胞转化 神经递质 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]