DDDC－乙酸丁酯联合萃取法制备~（201）TICI注射液  

PRODUCTION OF ^(201)TICI INJECTION WITH DIETHYLAMMONIUM DIETHYLDITHIOCARBAMATE- BUTYLACETATATE EXTRACTION METHOD

作　　者：方奕兵 伏永杭 苗林 赵永俊 潘企元 李柏[1] 刘佩华 王晗 冯经伶 郭新明 张苏[1] 陈洪涛 

机构地区：[1]中国科学院高能物理研究所

出　　处：《核化学与放射化学》1994年第1期28-29,共2页Journal of Nuclear and Radiochemistry

摘　　要：研究了二乙基二硫代氨基甲酸二乙铵（ＤＤＤＣ）对低浓度Ｐｂ、Ｔｌ（Ｉ）的萃取条件。在此基础上，发展了ＤＤＤＣ－乙酸丁酯联合萃取法，从能量为２９－２２ＭｅＶ、流强≤２０μＡ的质子束辐照后的金属铊靶中制备￣（２０１）ＴＩＣＩ注射液。１８批总量为３．１８×１０￣（１０）Ｂｑ的制备工作表明，产品的质量满足美国药典要求。化学产率８４％±２％，分离时间２．５－３ｈ，还可用于￣（２０３）ｐｂ的制备。注射液的异常毒性合格，小鼠体内分布和家兔显像实验结果良好。完成了临床１２４例验证实验，心肌显像清晰，诊断效果良好，受试人无任何不良反应。产品已获得卫生部颁发的新药证书。The extraction of Pb and Tl(Ⅰ)with butylacetate solution of diethylammonium di-ethyldithiocarbamate(DDDC)is studied.The DDDC-butylacetate extraction method for￣(201)TlCI injection production from natural Tl target irradiated by 29-22 MeV proton beam isdeveloped.￣(201) pb is separated from 0.3-0.4mol/l HNO_3 solution of Tl target with 0.2%DDDC-butylacetate and stripped into 4. 5mol/l HCl. The accumulated ￣(201)Tl is then oxidatedto Tl(Ⅲ)with KBrO_3 and separated from Pb-activity with butylacetate extraction and final-ly ,is stripped back into diluted H2SO_3. The results of 18 production runs of total amount3.18 × 10￣(10)Bq show that the quality of all injections meets the requirements of the UnitedStates Pharmacopeia. The chemical yield is 84%±2%, while the chemical separation time is2.5-3h. The method can also be used for production of ￣(203)pb with the chemical yield of 84%±3%and nuclear purity of>99.9%。The results of safety test, biodistribution in mice andrabbit imaging of the injections are good. The clinical experiments of 124 cases are per-formed. The quality of myocardial images and the efficiency of diagnoses are satisfactory.

关 键 词：氯化亚铊 注射液 乙酸丁酯 萃取 

分 类 号：R981[医药卫生—药品]