心肌显像剂^（68）Ga（BAT－TECH）的一些基本常数测定  

MEASUREMENTS OF SOME BASIC CONSTANTS OF￣(68)Ga(kAT-TECH)AS AN IMAGING AGENT

作　　者：陈华伟[1] 刘伯里[1] 

机构地区：[1]北京师范大学化学系

出　　处：《核化学与放射化学》1994年第4期213-218,共6页Journal of Nuclear and Radiochemistry

摘　　要：研究了心肌显像剂￣（６８）Ｇａ（ＢＡＴ－ＴＥＣＨ）的动力学性质，测定了它的热力学常数。实验结果表明，ＢＡＴ－ＴＥＣＨ与柠檬酸镓的配体交换反应为二级反应，反应速率常数ｋ为０．５０ｌ／ｍｏｌ·ｓ，反应活化能Ｅ＿ａ＝５６．６ｋＪ／ｍｏｌ；￣（６８）Ｇａ（ＢＡＴ－ＴＥＣＨ）的稳定常数ｌｇβ＝１４．９，配体ＢＡＴ－ＴＥＣＨ的四级氢解离常数ｐＫ＿１＝４．６２，ｐＫ＿２＝７．６８，ｐＫ＿３＝８．６８，ｐＫ＿４＝１１．２。The kinetic properties of a new myocardial imaging agent ￣(68)Ga(BAT-TECH)are investiga-ted and its thermodynamic constants are measured.The results are as follows:Citrate→BAT-TECH exchange reaction order is second-order;reaction rate k=0.50l/mol·s;activation energyE_a=56. 6kJ/mol;the stability constant of ￣(68)Ga(BAT-TECH)lgβ=14.9;the acid dissociationconstants of BAT-TECH pK_1=4.62 ,pK_2=7.68,pK_3=8.68,pK_4=11.2.

关 键 词：心肌显像剂 镓68 热力学常数 

分 类 号：R981.2[医药卫生—药品]