老年患者周围血T淋巴细胞亚群变化  

Variations of total T cell and T-lymphocyte subgroups in aged patients

作　　者：朱云[1] 郑国云[1] 侯风喜 王淑梅[1] 马瑞敏[1] 

机构地区：[1]河南医科大学第一附属医院内科

出　　处：《河南医科大学学报》1994年第1期51-53,共3页Journal of Henan Medical University

摘　　要：应用抗人Ｔ淋巴细胞单克隆抗体ＯＫＴ系列检测３０例健康老年人，４２例慢性肺心病，１５例恶性肿瘤，２１例高血压病患者外周血Ｔ淋巴细胞亚群的变化。结果显示，慢性肺心病组及恶性肿瘤组ＯＫＴ３百分率、ＯＫＴ４百分率显著降低，ＯＫＴ８百分率无明显变化，致ＯＫＴ４／ＯＫＴ８比值降低。慢性肺心病急性加重期ＯＫＴ３百分率和ＯＫＴ４百分率低于缓解期。结果提示老年人细胞免疫功能减弱，尤其是Ｔ淋巴细胞亚群比例失调是导致感染、恶性肿瘤等多种老年病的发生、发展的重要原因之一。This paper describes the variations of the total T cell and the T-lymphocyte subgroups in 108 aged people.They were divided into 4 groups:Group A,the patients with chronic pulmonary heart disease.Group B,those with malignant tumour;Group C,those with hypertension and Group D,control group.The results obtained by fluoroimmunoassay with OKT series in monoclonal antibodies revealed that the percentages of T_3 and T_4 in Group A and B were significantly lower than those in the control group(P<0.01),and the percentages of T_8 in Group A and B were similar to those in the control group,so that the ratios of T_4/T_8 in the patient groups were significantly lower than those in the control group(P<0.01).The percentages of T_3 and T_4 in the attacking stage were significantly lower than those in the stable stage of chronic pulmonary heart disease.The results suggest that the abnormal immune regulation may be one of the important factors making the elderly people susceptible to diseases,and that it may be one of the important causes of the severe conditions of the elderly patients.

关 键 词：老年人 T细胞亚群 抗体 肺心病 

分 类 号：R592[医药卫生—老年医学]