苯对作业工人免疫功能的影响  

Effect of benzene on immunity function of exposed workers

作　　者：许东[1] 陈小玉[1] 李时恩[1] 陈琛[1] 杨廷璋[1] 高丽暖 

机构地区：[1]河南医科大学劳动卫生职业病教研室,郑州纺织机械厂职工医院

出　　处：《河南医科大学学报》1994年第3期211-214,共4页Journal of Henan Medical University

摘　　要：对９４例苯作业人员的免疫功能调查表明：ＷＢＣ异常检出率为２５％，是对照组的３．５７倍（Ｐ＜０．０５）：ＴＬＣ为５７．８３％，低于对照组６７．７６％（Ｐ＜０．０１）；ＷＢＣ正常者中ＴＬＣ仍低于对照（Ｐ＜０．０１）。ＴＬＣ与ＷＢＣ呈正相关（ｒ＝０．４６３５，Ｐ＜０．０１）。免疫球蛋白ＩｇＡ降低，ＩｇＭ升高（Ｐ＜０．０１）。提示苯可以引起机体免疫功能降低，应注意对接触者进行免疫机能监视。ＴＬＣ的降低先于ＷＢＣ，可以认为是苯中毒早期的一个较为敏感的客观指标，用于苯中毒的早期诊断及疗效判定有一定实用价值。The immunity function of 94 workers who were exposed to benzene was investigated.The results showed that the rate of abnormal WBC was 25%, 3.57 times as high as that of the control group (P<0.01); that TLC(57.87%) was lower than that of the control group(67.76%,P<0. 01);that TLC of the exposed workers, whose WBC were normal, was lower as compared with that of the control group(P<0.01);that there was also positive correlation between TLC and WBC (r=0.4635,P<0.01);and that immunoglobin IgA was lower and IgM was higher than those of the control group(P<0.01). The results suggested that the drop of human immunity function might be caused by the exposure to benzene. Immunity funciton detection should be taken in exposed workers. Because the drop of TLC was earlier than that of WBC,TLC can be considered as a sensitive index to early benzene poisoning.So,TLC test would be of some value in diagnosing the cases of benzene poisoning and determining the curative effects.

关 键 词：淋巴细胞 免疫功能 苯中毒 

分 类 号：R135.12[医药卫生—劳动卫生]