阿魏酸钠对离体大鼠缺血心肌再灌注损伤的影响  

Effect of ferulic acid sodium on the reperfusion injury of the isolated ischemic myocardium of rats

作　　者：傅春景 张建芳[1] 黄幼田[1] 吕杰胜[1] 杨红艳[1] 马秀云[1] 

机构地区：[1]河南医科大学病理生理学教研室,河南医科大学附属卫校

出　　处：《河南医科大学学报》1994年第4期344-346,共3页Journal of Henan Medical University

摘　　要：为探讨缺血心肌再灌注损伤的防治措施，采用改良的Ｌａｎｇｅｎｄｏｒｆｆ法建立离体大鼠缺血心肌再灌注模型，观察阿魏酸钠在缺血心肌再灌注过程中的作用。结果显示：阿魏酸钠能够抑制丙二醛及血栓素Ｂ２的产生，减轻心肌水肿及乳酸脱氢酶的释放，并能促进６－酮－前列腺素Ｆｌα的产生。结果初步提示：阿魏酸钠具有抗缺血心肌再灌注损伤的作用。This experiment was carried out with the improved Langendorff method to set up the reperfusion model of the isolated ischemic myocardium of rats so as to study the prophylac tic-therapeutic measure for the reperfusion injury of the ischemic myocardium.The effect of ferulic acid sodium during the process of ischemia reperfusion was observed.The findings showed that ferulic acid sodium was able to restrain the production of molondialdehyde and thromboxane B2,to alleviate myocardial edema and the release of lactic dehydrogenase,and to promote the production of 6-keto-PGF1a.The results prove that ferulic acid sodium plays an important role in resisting the reperfusion injury of the ischemic myocardium.

关 键 词：阿魏酸钠 再灌注损伤 血栓素B2 心肌缺血 

分 类 号：R285.5[医药卫生—中药学] R965[医药卫生—中医学]