不同时间等容血液稀释对犬急性心肌梗塞左室功能的改善作用  

Improvement of left ventricular function in dogs with acute myocardial infarction with isovolumetric hemodilution at different times

作　　者：吕杰胜[1] 张连平[1] 汪丽娟[1] 宋伟[1] 鄢文海[1] 黄幼田[1] 王柏生[1] 汤宁[1] 李海燕[1] 

机构地区：[1]河南医科大学病理生理学教研室,河南医科大学第一附属医院急诊室,河南医科大学第一附属医院内科

出　　处：《河南医科大学学报》1994年第4期302-306,共5页Journal of Henan Medical University

基　　金：河南省科委资助

摘　　要：在麻醉开胸纯氧呼吸状态下的犬急性心肌梗塞（ＡＭＩ）模型上，观察以右旋糖酐４０在不同时间（ＡＭＩ前１ｈ、２４ｈ和ＡＭＩ后３０ｍｉｎ）行等容血液稀释对犬ＡＭＩ６ｈ内左室功能（±ｄｐ／ｄｔｍａｘ、ＬＶＳＰ）的改善作用。结果表明：ＡＭＩ后３０ｍｉｎ行血液稀释可使＋ｄｐ／ｄｔ－ｍａｘ明显升高（Ｐ＜０．０５）；而ＡＭＩ前１ｈ、２４ｈ行血液稀释不仅使ＡＭＩ后＋ｄｐ／ｄｔ－ｍａｘ明显升高，ＬＶＳＰ与－ｄｐ／ｄｔｍａｘ也明显升高（Ｐ＜０．０５）。提示：①不同时间行等容血液稀释对犬ＡＭＩ后左室收缩功能均有改善作用；②提前稀释血液不仅改善左室收缩功能，也能改善左室舒张功能。The effect of isovolumetric hemodilution with dextran 40 at different times on the left ventricular function in the dogs with acute myocardial infarction(AMI) during 6 hours was evaluated.All animals were anesthetized,chest opened and ventilated with pure oxygen.The results were as follows:compared with the control group(no treatment was given before and after coronary occlusion),+dp/dt-max increased in the groups of prior hemodilution and the group of hemodilution after coronary occlusion (P<0.05),LVSP and-dp/dt-max were obvioulsy improved in the groups of prior hemodilution.The result suggested that:①hemodilution with dextran 40 at different times could improve systolic function;②prior hemodilution could not only further improve the systolic function of the left ventricle but also the diastolic function of the left veictricle.

关 键 词：心肌梗塞 血液流变学 心脏功能 血液稀释 

分 类 号：R542.220.5[医药卫生—心血管疾病] R972[医药卫生—内科学]