尿白蛋白和NAG同功酶测定对糖尿病肾病的早期诊断价值  

Measurement of UAE and NAG isoenzymes in early diagnosis of diabetes nephropathy

作　　者：苏天水[1] 李光升[1] 何燕霞[1] 燕桂香[1] 张玉凤[1] 欧阳安[1] 

机构地区：[1]河南医科大学医学检验系,河南省医学科学研究所

出　　处：《河南医科大学学报》1994年第4期330-332,共3页Journal of Henan Medical University

基　　金：河南省卫生厅资助

摘　　要：６５例糖尿病患者按血糖控制情况分为ＤＭ１ＤＭ２ＤＭ３３组，同时选择糖耐量、胰岛素正常者２２人作对照。测定了糖化血红蛋白（ＨｂＡｌ）、尿蛋白、尿微量白蛋白、尿Ｎ－乙酰－Ｂ－Ｄ－ｒ氨基葡萄糖苷酶（ＮＡＧ）及同功酶ＮＡＧ－Ｂ。结果显示糖尿病各组尿白蛋白排出率、ＮＡＧ和ＮＡＧ－Ｂ均显著高于对照组。糖尿病组ＮＡＧ－Ｂ活性和尿白蛋白排出率呈现正相关。结果提示测定尿白蛋白和ＮＡＧ－Ｂ对糖尿病早期肾脏并发症的诊断有一定价值。The N-acetyl-B-D-glucosaminidase(NAG),HbA1,urinary protein and microalbumin were measured in 65 patients with diabetes of three groups.The NAG,NAG-B activity and urinary microalbumin were greatly increased in all patients as compared with the controls.A significantly positive correlation was observed between the NAG-B and the urinary albumin excretion rate(UAE).The results show that the measurement of UAE and NAG-B activity is useful in early diagnosis of diabetes nephropathy.

关 键 词：氨基葡萄糖苷 同功酶 尿 白蛋白 糖尿病 肾病 

分 类 号：R587.204[医药卫生—内分泌] R446.122[医药卫生—内科学]