胎儿黑质发育的电镜观察  

ELECTRON MICROSCOPIC OBSERVATION OF THE DEVELOPMENT OF SUBSTANTIN NIGRA IN HUMAN FETUS

作　　者：周明付[1] 林玲[1] 张华[1] 汤善钧[1] 聂正明[1] 周祥庭 

机构地区：[1]河南医科大学解剖学教研室

出　　处：《河南医学研究》1994年第4期313-316,共4页Henan Medical Research

基　　金：国家自然科学基金

摘　　要：本实验应用透射电镜观察了水囊引产的４～９月正常胎儿黑质发育的特征。结果如下：①黑质神经元在胎龄第４月表现为不成熟细胞的超微结构特征。随着进一步发育，神经元核异染色质逐渐减少，细胞质和细胞器逐渐增多，至胎龄第９月，黑质神经元的超微结构已接近生后细胞的特征；②在胎龄第４月的黑质标本中未见突触结构，随着发育在某些相邻细胞突起的相对膜增厚，但尚未见明显的突触活性点，至第９月时可见典型的突触结构，且大部分为对称型突触，含有圆形清亮囊泡和明显的突触活性点。以上结果提示，胎儿黑质在第４月发育尚不成熟，至第９月已接近成熟。Ultrastrctural characteristics of the development in normal human fetal sub-stantia nigra from month 4 to month 9 have been observed under electron microscopy. Theresults were as follows :①The characteristics of immature cells were seen at embryonicmonth 4.The amount of nuclear heterochromatin decrease gradually ,but cytoplasmic and or-ganelle increase gradually with development of neurons of substantia nigra.Ultrastructuralcharacteristics of neurons of substantia nigra at embryonic month 9 have closed to postnatalsubstantia nigra. ②Synaptic junctions were not found at embryonic month 4.The thickeningof the membrane in some terminal of processes approximal was seen,but synaptic active zonewas not obvious at month 6～7.Synaptic junctions were seen and most of them are symmetri-cal synapses that contain round clear vesicles and obvious synaptic active zone. These datasuggest that neurons of substantia nigra is immature at embryonic month 4 and have closedto mature at embrvonic month 9.

关 键 词：黑质 发育 胎儿 神经元 生理学 电子显微镜 

分 类 号：R714.51[医药卫生—妇产科学]