奥咪拉唑对空肠上皮细胞膜酶活性的影响  

OMEPRAZOLE ON MUCOSAL ENZYME ACTIVITIES OF RAT SMALL INTESTINE

作　　者：徐亚萍[1] 刘景超[1,2] 杜俊生[1] 花井洋行 金子荣藏 

机构地区：[1]河南中医学院校医院 [2]河南中医学院中医系

出　　处：《河南医学研究》1994年第4期307-309,共3页Henan Medical Research

摘　　要：新一代抗消化性溃疡新药奥咪拉唑（ｏｍｅｐｒａｚｏｌｅ）在发挥强力抑制胃酸分泌的同时，国外不少文献报道可引起腹泻等消化吸收障碍现象。本研究通过在胃酸分泌抑制状态下，对空肠上皮细胞膜酶活性的测定，提出引起消化吸收障碍的机制与Ｎａ＋，Ｋ＋－ＡＴＰ酶活性低下及二次性主动转运机能障碍所致的糖，氨基酸吸收障碍有关。The effect of omeprazole,a H+,K+-ATPase inhibitor,was investigated onmucosal enzyme activities of rat jejunum. Omeprazole ( 30 mg per kg body weight,once aday)was administered intraperitoneally for 4 weeks,Na+,K+-ATPase and Ca2+-ATPase ac-tivities were significantly inhibited but leucine aminopeptidase activity was increased withomeprazole treatment.The drug had significant dose-related inhibitory effects on these en-zyme activities. These changes were completely reversible,after withdrawal the drug. Thegrowing rate treated with omeprazole was significantly decreased as compared to the controlgroup. Cimetidine,a H2-receptor antagonist(100mg per kg ,twice a day )showed similar re-sults. These findings suggest that antisecretagogues such as omeprazole or cimetidine mightmfluence several enzyme activities of rat intestinal mucosa and that the decrement of Na+,k+and Ca2+-ATPase activities could cause maldigestion and maiabsorption of Na+or Ca2+.

关 键 词：奥咪拉唑 溃疡病 药物 空肠上皮 细胞膜 酶 

分 类 号：R975.6[医药卫生—药品]