“717”复方中药制剂对内毒素休克大鼠肝、肺损伤保护作用的形态学研究  

THE PROTECTIVE EFFECT OF"CHINESE MEDICINE-717"AGAINST HEPATIC AND PULMONARY TNJURY INDUCED BY ENDOTOXIN IN RATS

作　　者：谢予萍 唐利立[2] 刘世坤[2] 谭琛[2] 熊晓芳[2] 罗正曜[2] 万兰清[3] 马超英[3] 耿耘[3] 吴伟[3] 

机构地区：[1]湖南医科大学口腔病理教研室 [2]湖南医科大学病理生理教研室 [3]湖南医科大学江西中医学院

出　　处：《湖南医科大学学报》1994年第3期207-210,共4页Bulletin of Hunan Medical University

基　　金：江西中医学院国家自然科学基金资助课题

摘　　要：采用内毒素(ET)休克大鼠模型,在光镜、电镜下观察了"717"复方中药制剂(717)对 ET 休克大鼠肝、肺损伤的影响。结果表明:ET 组肝细胞呈小灶性或不规则片状坏死,窦内皮细胞膜损伤严重;肺泡壁明显增厚,毛细血管扩张充血,肺泡腔变小、消失甚至肺实变;肝、肺均有大量中性白细胞浸润。717+ET 组其病变明显减轻。提示717对 ET 休克大鼠肝、肺损伤有保护作用。The aim of this investigation is to study morphologically the protective effect of complex prescription 717 (chinese medicine) on hepatic and pulmonary injury induced by endotoxin (ET) in rats. The results of light and electron microscopic examination showed that in the ET group there were small necrotic foci and irregular sheets of necrosis in the hepatic parenchyma. The endothelial cells of the sinusoids wall were injured severely. The capillaries in the pulmonary wall were congested and became thicker. A large number of polymorphonu- clear leukocytes with a few red cells were filled in the alveolar lumens which might become solid and normal structure disappeared. The hepatic and pulmonary lesions in 717+ET group revealed the same as in ET group but were lessened in appearance. The morphological data demonstrated that 717 is an effective drug to decrease the degree mechanism of hepatic and pulmonary endotoxic injury in rats. This effectiveness was briefly discussed.

关 键 词：休克 717复方中药 制剂 病理学 肝 肺 

分 类 号：R285.5[医药卫生—中药学]