苯溴马龙与磺丙舒治疗痛风的随机对照研究  

A Randomized Controlled Study of Benzbromarone and Probenecid in the Treatment of Gout

作　　者：梁德荣[1] 徐楠[1] 张辉明[1] 蔡永宁[1] 张慧琳[1] 

机构地区：[1]华西医科大学临床药理研究所

出　　处：《华西医学》1994年第4期405-408,共4页West China Medical Journal

摘　　要：本文对７４例痛风患者进行随机对照试验，比较苯溴马龙（ｎ＝３９）与丙磺舒（ｎ＝３５）的临床疗效和安全性，结果表明，苯溴马龙组（苯组）总有效率高于丙磺舒组（丙组），分别为９７．４４％和８５．７１％和８５．７１％（ｐ＞０．０５）；治后１周血尿酸下降值苯组高于丙组，分别为２２８．４９±９１．０１和１６８．０３±１３７．４３μｍｏｌ／Ｌ（ｐ＜０．０５）；同期尿酸排泄苯组亦高于丙组。两组副反应发生率分别为２０．５１％及５４．２９％，苯组明显低于丙组（ｐ＜０．００１）。本文表明苯溴马龙较丙磺舒显效更快、副反应少、耐受性良好。A randomized controlied study was carried out in Chinese gout patient to compare the efficacy and safety of benzbromazone with that of probenecid. 74 patients (F2 M72, agde 29─78 years) were included. 39 cases were trated with benzbromazone (A group) 50mg daily and 35 cases participated in probenecib (B) group. The dosage of controls was 250mg twice daily for 3 days followed by gradually increasing up to 500mg three times daily in 10 days. The period of treatment was 12 weeks in both.The overall clinical efficacy rates were 97.44% in group A and 85.71% in group B (p>0.05) . After 7 days of tratment the serum urate levels in both groups were declined greatly (from 568. 26 ± 78. 17 and 467.11 ± 85.21 μmol/L to 279.77 ± 80. 08 and 304. 99 ±123.03 μmol/L respectively) and they remain stable on futher therapy. In different therapeutic stages the decreasing values of the serum uric acid in group A was greater than that in group B, especially after one week therapy, they were 228.49± 91.01 and 163.03± 137. 43 μmol/L respectively (p<0.05) . At the same stage urinary uric acid excretion increased from 2. 41 ± 1. 30 to 2. 82 ± 1.88 mmol/24h (p<0. 05) in group A, but no significant change was observed in group B (from 2. 05 ± 1. 54 to 2. 04 ± 0. 88 mmol/24h ) .The incidences of acute joint attack during therapy were 5.13% and 17. 14% (p>0. 05)axid the side-effect rates were 20.51% and 54.29% (p<0.001)in group A and B respectively. In conclusion, benzbromazone more rapidly anb strongly lowers the increased serum uric acid than probenecid. It is one of the effective and safe uricosurics,

关 键 词：苯溴马龙 丙磺舒 随机对照试验 痛风 

分 类 号：R589.705[医药卫生—内分泌] R969.4[医药卫生—内科学]