离心式搅拌细胞培养反应器的流体循环及氧传递规律  

Studies of Fluid Circulation and Oxygen Transfer in a New Kind of Cell Culture Bioreactor

作　　者：王斯靖[1] 张元兴[1] 范卫民 俞俊棠[1] 

机构地区：[1]华东理工大学生物化学工程研究所

出　　处：《华东理工大学学报（自然科学版）》1994年第6期764-768,共5页Journal of East China University of Science and Technology

摘　　要：研究了一种具有离心式搅拌器的新型细胞培养反应器的流体循环、混合特性及氧传递规律。采用这种离心式搅拌器，既充分利用了细胞提升式搅拌器的优点，又大幅度地提高了流体循环效率。氧传递速率、通气速率均与转达有关，其中通气速丰的影响最为显著。根据实验数据，建立了反应器中的氧传递和提升筒中流体流动的关联式。Fluid circulation,mixing and oxygen transfer processes were studied in a newkind of cell culture bioreactor with a novel centrifugal impeller.The advantages of the cell-lift impeller are incorporated,and the fluid circulation efficiency is enhanced sufficiently.Theoxygen transfer rate increases with aeration rate and rotating speed,with the former parame-ter being the most significantly.The volumetric oxygen transfer coefficients and the fluid cir-culation rates in the draft tube are correlated based on the experimental data.

关 键 词：混合 氧传递 离心式 搅拌器 流体循环 

分 类 号：TQ051.71[化学工程]