交沙霉素胶囊剂药代动力学和生物利用度研究  

STUDY ON THE PHARMACOKINETICS AND BIOAVAILABILITY OF JOSAMYCIN CAPSULE

作　　者：洪诤[1] 张三友[1] 张锦云[1] 张淑华[1] 强文安[1] 李良宏[1] 王浴生[1] 

机构地区：[1]华西医科大学,四川抗生素工业研究所

出　　处：《华西药学杂志》1994年第1期14-16,共3页West China Journal of Pharmaceutical Sciences

摘　　要：本文报道微生物效价法测定交沙霉素胶囊剂和片剂在８名成年男性健康受试者体内的药代动力学和口服胶囊剂的生物利用度。８名受试者接受单剂量（１０００ｍｇ）交叉给药（胶囊剂和片剂）后所得药－时曲线符合一室模型。其胶囊剂和片剂的平均药代动力学参数分别为：血清药物峰浓度（Ｃｍａｘ）：３．１２±１．１９与３．２４±０．８９ｍｇ／Ｌ，药物达峰时间（Ｔｍａｘ）：１．４６±０．４４与１．４９±０．５１ｈ，消除半衰期（ｔ１／２ｋｅ）：１．５９±０．３５与１．６３±０．１９ｈ，药－时曲线下面积（ＡＵＣ）：１０．９１±２．９５与１１．８０±２．９６ｍｇ／Ｌ．ｈ。其相对生物利用度以片剂为１００％，胶囊剂的相对生物利用度为９２．４５±１３．１５％。Pharmacokinetics and relative bioavailability of a single oraldose 1000mg josamycin capsule and tabletaccording to a cross over design were studied in eight normal male volunteers by bioassy method The results showed that the pharmacokinetics of oral administration josamycin in the healthy volunteers fitted a one-compartment model. The Cmax in capsule and tablet were 3.12±1.19 and 3.24 ± 0.89 mg/L,respectively,Tmax were 1. 46±0.44 and 1.49±0.51h,T1/2ke were 1.59 ± 0.35 and 1.63± 0.19h,AUC were 10.91 ±2.95 and 11.80±2.96mg/L。h,respectively.The relative bioavailability of josamycin capsule was92.45%。

关 键 词：交沙霉素 一室模型 生物利用度 

分 类 号：R969.1[医药卫生—药理学]