含酚醚中心功能基的大二环型穴醚的合成及配位性能  

Synthesis of Macrobicyclic Cryptands with a Phenol Ether Central Group and Their Complexation

作　　者：秦圣英[1] 杨玉社[1] 张安将[2] 

机构地区：[1]四川大学化学系,成都610064 [2]华西医科大学药学院,成都610041

出　　处：《化学学报》1994年第3期268-273,共6页Acta Chimica Sinica

摘　　要：４－氯－２，６－二羟甲基苯甲醚（２）与氯乙酸钠缩合，制得４－氯－２，６－二（羧甲氧基甲基）苯甲醚（４），由４经酰氯化生成４－氯－２，６－二（３－氯甲酰基－２－氧杂丙基）苯甲醚（５）后，再与相应的二氮杂冠醚３ａ，３ｂ和３ｃ反应制备标题化合物１ａ～１ｃ。用＾１Ｈ ＮＭＲ法研究了１ａ～１ｃ对碱金属离子的配位性能，讨论了分子内的中心功能基和底部大小对其ＩＲ，＾１Ｈ ＮＭＲ和配位行为的影响。Three novel macrobicyclic cryptanda 1a-1c were synthesized by the reaction of appropriate diaza-15-crown-5(3a), diaza-18-crown-6 (3b) and diaza-21-crown-7(3c) with 4-chloro-2, 6-bis(8-chlorocarbonyl-2-oxapropyl)anisole(5) preparing from 4-chloro-2, 6-bis (S-carboxyl-2-oxapropyl) anisole (4), which was obtained via the condensation of 4-chloro-2, 6-dihydroxymethyl anisole with sodium chloroacetate.The complexation of 1a-1c for alkali metal cations were investigated by 1HNMR. The influence of central group and bottom ring size in the molecules 1a-1c on IB, 1H NMR and conplexation behaviour was also discussed.

关 键 词：大二环型 穴醚 功能基 配位 酚醚 

分 类 号：O623.423[理学—有机化学]