香芹酮的双重Michael反应和在天然产物手性合成中的应用  

Double Michael Reaction of Carvone and Its Utilization in Chiral Synthesis of Natural Products

作　　者：赵玉芬[1] 赵荣宝 吴毓林[1] 

机构地区：[1]中国科学院上海有机化学研究所

出　　处：《化学学报》1994年第8期823-830,共8页Acta Chimica Sinica

基　　金：国家自然科学基金资助课题

摘　　要：香芹酮与α,β-不饱和酯顺利进行双重Michael加成反应,所得光学活性的[2.2.2]桥环化合物为一些天然产物的手性合成提供了十分有用的中间体.本文报道了这两方面的研究进展.The double Michael reaction of carvone and methyl methacrylate was described in detail. Its product, an optically active bicyclo [2.2.2]octane derivative, is a useful intermediate for the chiral synthesis of natural products. In this respect an elemene derivative and an intermediate for the synthesis of (+)-curdione were synthesized.

关 键 词：香芹酮 米歇尔反应 手性合成 

分 类 号：O629.9[理学—有机化学]