二取代双噁唑啉衍生物的合成及其在不对称环丙烷化反应中的应用  

Synthesis of Bis-oxazolines and the Application in Asymmetric Cyclopropanation

作　　者：杨智才[1] 钟民[1] 陈良[1] 

机构地区：[1]华东师范大学化学系,上海200062

出　　处：《化学学报》1994年第12期1218-1220,共3页Acta Chimica Sinica

基　　金：国家自然科学基金资助的项目.

摘　　要：通过双亚氨酯盐酸盐与手性胺醇反应简便地合成了二取代双(口恶)唑啉衍生物,并将其与铜配位运用于重氮醋酸酯对烯烃的不对称环丙化反应,不对称诱导反应光学产物收率最高达95%d.e.Bis-oxazolines were easily prepared from diethyl propanediimidoate dihydrochloride and chiral amino alchols. These bis-oxazolines were successfully applied to the reaction of alkyl diazoacetate with olefin to give optically active alkyl cyclopropanecarboxylate. The highest enantioselectivity achieved 95% d. e. in the catalytic cyclopropanation of iso-butene.

关 键 词：双恶唑啉 衍生物 合成 不对称环丙烷化 

分 类 号：O626.1[理学—有机化学]