低氧时大鼠肺外肺动脉羟脯氨酸含量的变化及川芎嗪对其影响  

Changes of Hydroxyproline Content in Extra- pulmonary Artery during Hypoxia and the Effect of Ligustrazine on it

作　　者：陈祥银[1] 严仪昭[1] 余丽君 李长城[1] 孙仁宇[1] 

机构地区：[1]中国医学科学院基础医学研究所

出　　处：《基础医学与临床》1994年第3期47-50,共4页Basic and Clinical Medicine

基　　金：八五课题

摘　　要：用改良的微量组织中羟脯氨酸（Ｈｐ）含量测定法，观察了常压低氧大鼠肺外肺动脉中Ｈｐ含量的变化及川芎嗪对其作用。结果表明，常压低氧１４天，肺动脉压明显升高，肺动脉Ｈｐ含量也明显增加，以ｕｇ／条动脉或ｕｇ／ｍｇ干重表示都类似。提示低氧引起肺外肺动脉胶原含量增加。还观察到川芎嗪对上述变化有明显抑制作用。ypoxic pulmonary hypertension model of rat was used in this investigation.The ckange of hydroxyproline(Hp)content in extra- pulmonary arteries and theeffect of ligustrazine on it were studied,The results showed that hypoxia (10%02, for l4 days) induced pulmonary hypertension(PAP increased from 19.4±0.9mmHg to 26.4±0.8mmHg, P<0.01)and increased Hp content of extra-pulmonarytartery (from 40.4±3.2ug/mg dry wt to 48.6± l.1ug/mg ,P<0.05).Ligustrazinereatment (80mg/ kg im)could inhibit both increased PAP and HP content inducedby hypoxia,The possible mechanism was discussed.

关 键 词：低氧 肺外肺动脉 胶原 川芎嗪 

分 类 号：R544.102[医药卫生—心血管疾病]