人良性增生前列腺及上皮和间质细胞的鸟氨酸脱羧酶活性  

Ornithine Decarboxylase Activity in Epithelia and Stroma of Human Benign Hyperplastic Prostates

作　　者：刘贤锡[1] 罗道春[1] 余东安 林毓琴[1] 赵春华[1] 徐祗顺[1] 张虞毅[1] 吴伟芳[1] 

机构地区：[1]山东医科大学生化教研室

出　　处：《基础医学与临床》1994年第4期54-56,共3页Basic and Clinical Medicine

基　　金：山东省自然科学基金

摘　　要：以比色法测定了正常人（８例）和良性前列腺增生症病人（２１例）前列腺组织的全匀浆、上皮和间质细胞中的鸟氨酸脱羧酶（ＯＤＣ）的活性。结果显示：正常组织的上皮部分ＯＤＣ活性高于间质部分，而增生组织相应的两部分ＯＤＣ活性无差异；增生组织的间质部分酶活性是正常组织该部分酶活性的２．５倍，两组间上皮部分的酶活性无差异；增生组织全匀浆的酶活性显著高于正常组织。结果表明前列腺组织中ＯＤＣ活性升高与良性前列腺增生症的发生有关。rnithine decarboxylase (ODC) activity was measured in 8 normal and 21 casesof benign hyperplastic prostates to investigate the relationship of ODC activitywith the pathogenesis of benign prostatic hyperplasia(BPH).The results were:1. ODC activity in epithelial fraction was higher than that of stromal fracion innormal subjects, while in hyperplastic tissues,no difference was found between thetwo fractions;2. ODC activity in stromal fraction increased significantly in BPHtissues,about 2.5 times that of normal prostates;3.ODC activity in whole tis-sue homogenate Was found significantly higher in BPH tissues than that of normalones. These results indicated that ODC was mainly localised in epithelia and in -creased significantly in stroma of hyperplastic prostates.The relationship pf incre-ased ODC activity in stroma of BPH tissue with the pathogefnesis of BPH、was dis-cussed.

关 键 词：鸟氨酸脱羧酶 前列腺增生 雄激素 

分 类 号：R697.32[医药卫生—泌尿科学]