高原低氧对喜马拉雅旱獭、高原鼠兔、缺氧敏感大鼠颈动脉体超微结构的影响  

EFFECT OF ALTITUDE HYPOXIA ON CAROTID BODY ULTRASTRUCTURE IN MARMOTA HIMALAYANA,OCHOTON A CURZONIAE AND HILLTOP SPRAGUE DAWLEY RAT

作　　者：陈钦铭 叶于聪 温佳林 

机构地区：[1]青海省高原医学科学研究所

出　　处：《兽类学报》1989年第3期221-225,共5页Acta Theriologica Sinica

摘　　要：应用扫描电镜结合透射电镜技术,对上海(海拔10米)的大鼠,5天内从上海急进到海拔3300米的大鼠,由北京引入西宁的子4代大鼠,同高原的喜马拉雅旱獭和高原鼠兔的颈动脉体微细结构进行对比观察。结果表明,高原低氧环境使由低海拔急进到高海拔的大鼠颈动脉体Ⅰ型细胞增生、肿胀、体积增大,胞浆中致密核心囊泡数量减少,线粒体变性肿胀,神经末稍中突触囊泡减少,Ⅰ型细胞表面微绒毛变性脱落;而喜马拉雅旱獭和高原鼠兔对高原低氧环境有较好的适应,未见缺氧损害征象。This investigation reveals with the ultrastructural effects of hypoxia in native plateau species Marmota himalayana (3300m above sea level), Ochotona curzoniae (3300m) and plateau-migrated rats (the fourth filial generation of the Wistar rats imported to Xining and migrated to 3300m),and the Hilltop Sprague Dawley rats divided into 2 groups: (l)quickly brought to altitude (3300m), (2)remained in Shanghai(control). Their left and right carotid bodies were investigated with transmission electron micro-scope and scanning electron microscope. There were an increase in the number of type I cells,decrease in the number of de-nse-cored vesicles, degenerated mitochondria, an increase in number and size of the vacuoles,decrease in the synaptic vesicle of the nerve endings and reduced microtriches in the surface of type I cell in the Sprague Dawley altitude-brought rats. However, no change had been observed in these indexes mentioned above in native O.curzoniae and M.himalayana at the same experimental conditions. The light damage of hypoxia of carotid bodies was observed in plateau-migrated Wistar rats.

关 键 词：旱獭 鼠兔 大鼠 颈动脉体 超微结构 

分 类 号：S858.902.2[农业科学—临床兽医学]