均匀设计及其在鸟嘌呤核苷酰化反应中的应用  

UNIFORM DESGIN AND ITS APPLICATION IN ACYLATION REACTION OF GUANOSINE

作　　者：谢惠芬 

机构地区：[1]上海第六制药厂

出　　处：《计算机与应用化学》1994年第1期67-69,共3页Computers and Applied Chemistry

摘　　要：鸟嘌呤核苷经酰化，酰解反应制得二乙酰鸟嘌呤和四乙酰核糖。本文用均匀设计及逐步回归分析寻找酰化反应的最佳条件，使二乙酰鸟嘌呤和四乙酰核糖的收率分别为９０．３２％和５９．６３％。N￣2-aretylguanine and tetracetyl-β-D-ribofuranose were prepared by guanosine through arylation, arylolysis.Searched the best condition of acylation reaction with Uniform Design and Analysis of Stepwise Regression. Yield of N￣2-acetylguanine and tetracetyl-β-D-ribofuranose were 90.32% and 59.63%.

关 键 词：鸟嘌呤核苷 均匀设计 酰化反应 

分 类 号：TQ464.3[化学工程—制药化工]