粉防已碱对阿霉素心脏损害大鼠的保护作用  

Aprotective effect of tetrandrine on the heart injury in rats induced by adriamycin

作　　者：李福全[1] 马春力[1] 张明远[1] 谭红[1] 李展宇[2] 胡绍芬 

机构地区：[1]佳木斯医学院基础药理教研室 [2]佳木斯医学院总局水稻所医院 [3]嘉阴县医院

出　　处：《佳木斯医学院学报》1994年第6期12-13,共2页

摘　　要：本实验观察了粉防已碱(Tetrandxine)对阿霉素心脏损害大鼠的保护作用结果表明:预先给予粉防已碱能使阿霉素心脏损害大鼠血清肌酸激酶(CPK)值下降,并提高血清和心肌组织中超氧化物歧化酶(SOD)的活性,降低丙二醛(MDA)含量与阿霉素(ADR)组相比有显著差异(P<0.05或 P<0.01)。The protective effect of tetrandrine on the heart injury in rats induced by adriamycin was observed.The result suggested that when tetrandrine was given,the CPK value and MDA content were decreased,while SOD activity in serum and myocardium was increased,with significant difference compared with ADR group(P<0.05 or P<0.01).

关 键 词：丙二醛 肌酸激酶 粉防己碱 大鼠 阿霉素 

分 类 号：R965.2[医药卫生—药理学]