镇痛灵对实验性急性肝损伤小鼠的影响  

Effect of Zhentongling (ZTL)on acute experimental hepatic injury in mouse

作　　者：马勇[1] 张惠光[1] 马青[2] 于翔辉[2] 吕密凯[2] 张景祥[2] 

机构地区：[1]佳木斯医学院第一附院内科 [2]佳木斯医学院生理教研室

出　　处：《佳木斯医学院学报》1994年第6期6-7,共2页

摘　　要：本工作观察镇痛灵(ZTL)对小鼠实验性肝损伤有保护作用。ZTL 可降低四氯化碳(CCl_4)致肝伤损小鼠血清谷丙转氨酶(GPT)和肝组织丙二醛(MDA)的升高幅度。结果提示:ZTL 可抑制 CCl_4所产生的脂质过氧化反应,清除体内自由基,减轻 CCl_4对肝细胞的毒性作用。A Protective effect of Zhentongling(ZTL) on experimental hepatic injury in mouse was observed.ZTL could decrease the elevation of serum GPT and the liver melondialdehyde con- temts in CCl_4-intoxicated mice.According to the results mentioned above,we proposed that ZTL could suppress response of lipid peroxidation,which produced by CCl_4 and clean free radicals and decreased CCl_4-toxic action on hepatic cells.

关 键 词：镇痛灵 四氯化碳 肝损伤 谷丙转氨酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]