川芎嗪对老龄小鼠超氧化物歧化酶活性和过氧化脂质含量的影响  

Effect of ligusticum wallichii on superoxidedismutase and lipid peroxide in elderly mouse

作　　者：高玉莲[1] 于小东 吕晶 郭忠兴[4] 张明远[4] 栗坤[4] 

机构地区：[1]佳木斯医学院第一附院 [2]佳市妇幼保健院 [3]伊春卫校 [4]佳木斯医学院药理教研室

出　　处：《佳木斯医学院学报》1994年第6期4-5,共2页

摘　　要：本文采用改良的邻苯本三酚自氧化法和 TBA 比色法测定盐酸川芎嗪注射液(0.2g/kg,0.4g/kg,0.8g/kg)对老龄小鼠红细胞超氧化物歧化酶活性和心、肝中过氧化脂质含量。结果表明,川芎嗪注射液能显著提高老龄小鼠红细胞中超氧化物歧化酶活性(P<0.01);显著降低心、肝中过氧化脂质含量(P<0.01)。故具有延缓衰老作用。Superoxidedismutase activity and lipid peroxide contents in the heart and liver of eldely mouse were measured using improved pyroved pyrogallol and TBA colorimerie method.The result showed that ligusticum wallichii increased superoxidedis mutase aetivty of in the RBC (P<0.01)decreased the lipid peroxide contents in the heart and liver(P<0.01),suggesting its anti-senility effect.

关 键 词：川芎嗪 老龄小鼠 超氧化物歧化酶 过氧化脂质 

分 类 号：R284.1[医药卫生—中药学]