实验性糖尿病大鼠主动脉超微结构研究  

Ultrastructural study on the aortic wall in rats with STZ-i nduced diabetes

作　　者：赵西原 吴家祥[1] 张凤兰[1] 蔡世喜 李艳丽[3] 

机构地区：[1]白求恩医科大学病理解剖教研室 [2]白求恩医科大学一院中心实验室 [3]白求恩医科大学一院化验科

出　　处：《白求恩医科大学学报》1989年第5期459-463,共5页Journal of Norman Bethune University of Medical Science

摘　　要：本实验对STZ—DM大鼠的主动脉进行了超微结构观察。结果显示,DM大鼠血浆胰岛素水平明显降低,血糖含量明显增高、血浆TC、LDL—C、LDL—C/HDL—C、TC/HDL-C值明显增高,HDL—C明显降低,与对照组比较均有显著差异(P<0.01)。电镜下,DM大鼠主动脉有早期AS病变。结果表明,急性实验性DM,由胰岛素绝对缺乏所致的高血糖、高TC、高LDL—C以及低HDL—C血症,可能与主动脉早期AS病变的形成密切相关。Ultrastructue of the aortic wall in rats with diabetes induced by STZ is studied.The radioimmunologic and biochemical data obtained show a significant decrease in plasma insulin level and a significant increase in blood glucose content in diabetic as compared with the normal rats (P<0.01).TC, LDL-C, LDL-C/HDL-C and TC/HDL-C are increased, but HDL-C is significantly de-creased in diabetic rats.Under SEM and TEM, early atherosclerotic ohanges are found in the aortic wall of diabetic rats.The results show that,in acute exper-imental diabetes, hyperglycemia, hypercbolesterolemia, hyperlipemia of LDL-C and hypolipemia of HDL-C resulted from absolute hypoinsulinism may be close-ly related to the formation of early aortic atherosclerotic changes.

关 键 词：糖尿病 主动脉 超微结构 鼠 脂蛋白 

分 类 号：R587.1[医药卫生—内分泌]