电离辐射对细胞中ADPRT的激活与诱导作用  

Activation and ineuction of ADP-ribosyltransferase in cells by γ-ray irradiation

作　　者：周平坤[1] 刘学英 孙文种[1] 章扬培[1] 魏康[1] 

机构地区：[1]军事医学科学院放射医学研究所

出　　处：《军事医学科学院院刊》1994年第1期18-20,共3页Bulletin of the Academy of Military Medical Sciences

摘　　要：研究了不同剂量γ线照射对小鼠ＳＲ－１细胞中ＡＤＰＲＴ活性的影响。结果表明５０Ｇｙ以上剂量照射对ＡＤＰＲＴ的催化反应有明显的激活作用，并且随照射剂量的增加而提高。此外，细胞受０．０１Ｇｙ低剂量照射之后一定时间，无论是再照射还是不照射５０Ｇｙ大剂量，所测得的ＡＤＰＲＴ活性都明显高于未受低剂量照射的细胞，表明低剂量辐射对细胞中ＡＤＰＲＴ具有诱导作用。The effect of different doses ofγ-ray irradiation on the ADp-ribosyltransferase(ADPRT) activity inmouse SR-1 cells was studied.When the cells received 50 Gy and over of γ-ray irradiation,the ADPRT wasimmediatly activated,and the enzyme activation was dose-dependent.When the cells were pre-exposed to 0.01Gy low dosey γ-rays, with or without 50 Gy irradiation 18 hours later,the level of ADPRT activitv in the cells wasevidently higher than that in the cells without low dose pre-exposure. This results showed the induction effect ofADPRT in SR-1 cells by low dose radiation.

关 键 词：低剂量辐射 辐射效应 诱导 ADPRT 

分 类 号：R594.802[医药卫生—内科学]