异佛司可林对大鼠及豚鼠全血血小板聚集的抑制作用  

The Inhibitory Effects of Isoforskolin on Rat and Guinea Pig Platelet Aggregation in the Whole Blood

作　　者：马国义[1] 陈植和[1] 王德成[1] 

机构地区：[1]昆明医学院药理教研室

出　　处：《昆明医学院学报》1994年第1期18-21,共4页Journal of Kunming Medical College

基　　金：云南省应用基础研究基金

摘　　要：本文采用阻抗法测定血小板聚集性，观察异佛司可林对大鼠和豚鼠全血血小板聚集的影响，结果表明：异佛司可林对ＡＤＰ，ＡＡ诱导的大鼠及ＰＡＦ诱导的豚鼠全血血小板聚集均有抑制作用，ＩＣ５０分别为３．４５，３．８３和２．８５ｍｇ·Ｌ－１，静注异佛司可林（５．１０ｍｇ·ｋｇ－１）对上述３种诱导剂诱导的聚集也有抑制作用，提示异佛司可林对血小板３条活化途径的抑制无明显选择性，其抗血小板聚集作用的机理可能是通过激活腺苷酸环化酶，升高血小板内ｃＡＭＰ水平实现的．Isoforskolin is one of the active ingredients isolated from Coleus forskohlii native to Yunnan. The inhibitory effects ofisoforskolin on rat and gunea pig whole platelet aggregation were studied. Isoforskolin inhibited significantly both rat whole platelet aggregation induced by adnosine diphosphate(ADP)/arachidonic acid(AA) and guinea pig whole platelet aggregation induced by platelet activating factor(PAF) in vitro, The inhibition was dose-dependent,IC50 were 3.35,3.83 and 2.85 mg·L-1 respectively.Isoforskolin(5,10 mgkg-1)iv also suppressed rat and guinea pig whole ptelet aggregation induced by the above three inducers.The maximal effects were occured at l0 min after administration, and the inhibitory effects lasted for 2 hours. These resultes suggest that isoforskolin is one of the potent inhibitors of platelet aggregation,The mechanism of the antiplatelet aggregation of isoforskolin might be that it activate adenylate cyclase and increasing cyclic AMP in platelets.

关 键 词：异佛司可林 环磷酸腺苷 血小板聚集 

分 类 号：R965[医药卫生—药理学]