右旋异可利定对失血性休克家兔肠系膜微循环的影响  

Effects of d-Isocorydine on Mesenteric Microcirculation of Rabbits with Hemorrhagic Shock

作　　者：吴信娴 周定邦[1] 吴晓芳[1] 魏书均[1] 

机构地区：[1]昆明医学院生理学教研室

出　　处：《昆明医学院学报》1994年第1期44-47,共4页Journal of Kunming Medical College

基　　金：云南省卫生厅应用基础研究基金

摘　　要：用２２只家兔，引起失血性休克并维持２０ｍｉｎ。８只静注０．５％右旋并可利定２．５ｍｇ·ｋｇ－１；６只静注０．０２％多巴胺０．１ｍｇｋｇ－１；其余８只静注等量生理盐水。结果显示右旋异可利定能增加失血性休克家兔的体动脉血压，其升压幅度和持续时间均较多巴胺高而长。结果表明，右旋异可利定能舒张肠系膜微动脉和微静脉及加快血流速度；且能使一些在失血性休克后关闭的毛细血管重新开放。rabbits,weighting 2.2± 0.1 kg(±s),suffering from hemorrhagic shock caused by femoral artery bleeding was maintained for twenty minutes.8 rabbits were injected with 0.5%d-Isocorydine(2.5 mg) iv; 6 with 0.02% Dopamine(0.1 mg·kg-1)iv;and other 8 with the same volume of saline.The experimental results showed that d-Isocorydine could increase carotid pressure.Range and duration of increasing carotid pressure were higher and longer than those with Dopamine.It can relax arteriole and venule of mesenteric;and increase circulatory blood flow.Furthermore,it can reopen some capillaries after hemorrhagic shock.

关 键 词：右旋异可利定 休克 微循环 出血性 

分 类 号：R972.5[医药卫生—药品]