东莨菪碱作为喉部表面麻醉前用药的效果观察  

Experimental study on using atropine or scopolamine before surface anesthesia of larynx

作　　者：吴家廉[1] 刘永竑 吴乐群[1] 周远大[1] 何海霞[1] 李远忠 

机构地区：[1]重庆医科大学第二医院耳鼻咽喉教研室,重庆医科大学第一医院临床药理教研室

出　　处：《临床耳鼻咽喉科杂志》1994年第3期141-143,共3页Journal of Clinical Otorhinolaryngology

摘　　要：报告用小鼠作激怒试验，比较东莨菪碱和阿托品对疼痛刺激的影响。结果表明东莨菪碱有明显的中枢镇静作用。继而在临床上于麻醉前分别肌注东莨菪碱和阿托品，以及二药分别加服安定，即以四组各观察５０例喉部手术患者。结果：东莨菪碱或其合并安定的患者心率明显减慢，并减少表面麻醉剂用量和缩短手术时间。提示东莨菪碱或其合并安定作为喉部麻醉前给药优于阿托品。To compare the effects of atropine with scopolamine on central emotion response induced by pain, the mice given atropine or seopolamine were stimulated by electric current change to provoke mice to anger. The result showed that scopolamine had a powerful center sedative effect. 200 patients were divided into four groups, 50 patients per group, the patients were injected scopolamine, atropine,scopolamine combined with diazepam and atropine combined with diazepam before surface anesthesia respectively.The results indicated that scopolamine alone or combined with diazepam could significantly reduce heart rate,anesthetic dose and shorten operation time. We think that scopolamine or scopolamine in combination with diazepam before surface anesthesetic application is much better than atropine or atropine combination with diazepam.

关 键 词：喉部表面麻醉 东莨菪碱 阿托品 

分 类 号：R971.2[医药卫生—药品]