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作 者:朱旅云[1] 马淑萍[1] 黄希正[1] 赵树元[1] 吴代英
机构地区:[1]河北省人民医院,河北省医学科学院
出 处:《临床心血管病杂志》1994年第6期327-329,共3页Journal of Clinical Cardiology
摘 要:应用氨力农治疗35例严重充血性心力衰竭(CHF),治疗前后测定左室舒张功能及血浆中肾素活性(PRA)、血管紧张素Ⅱ(AⅡ)和醛固酮(ALD)浓度。结果显示,氨力农可明显改善CHF患者的左室舒张功能及降低血浆中AⅡ和ALD浓度。其作用机理可能在一定程度上与神经体液因素有关。Abstract The left ventricular diastolic function and plasma renin activity(PRA),concentration of plasma angiotensin Ⅱ(AⅡ) and plasma aldosterone(ALD) were determined before and after amrinone was given to 35 patients with severe congestive heart failure(CHF).The results showed that the amrinone could improve abviously the left ventricular diastolic function in patients with CHF,especially in cases with coronary artery disease who had lower levels of plasma AⅡ and plasma ALD before therapy,and decrease significantly the concentrations of plasma A Ⅱ and plasma ALD.It indicates that the mechanism of action of amrinone to a certain extent is associated with the neurohumoral factors.
分 类 号:R541.610.5[医药卫生—心血管疾病] R969.4[医药卫生—内科学]
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