地奥心血康对实验性心肌损伤的保护作用及其机理  

The protective effect of diaoxinxuekang on experimental myocardium injury and its mechanism

作　　者：袁恩荣[1] 刘泽[1] 陈建萍[2] 

机构地区：[1]广州第一军医大学珠江医院心内科,510282 [2]中国科学院成都生物研究所制药厂

出　　处：《临床心血管病杂志》1994年第1期34-36,共3页Journal of Clinical Cardiology

摘　　要：大鼠皮下注射异丙肾上腺素(ISO)造成心肌损伤模型,其心肌含水量、血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、心肌钙含量、丙二醛含量及心肌病理学损伤程度分级均有显著增加(均P<0.01).如同时应用地奥心血康(DK;20mg/kg,ip),则上述指标比不用DK者分别减少2.6%、46.6%、60.9%、37.2%和30.5%,病理分级也显著降低(均P<0.05).表明DK对缺血损伤心肌具有明显的保护作用.其机理主要为防止心肌细胞钙超载及减轻氧自由基损伤.In the model of rat myocardial damage by intraperitoneally inject isoproterenol, the serum level of CK and LDH.the myocardial water, calcium and malondialdehyde content and the degree of myocardial pathological damage were greatly increased (all P<0. 01) . If applying diaoxinxuekang (20mg. kg-1) at the same time, the above indexes decreased respectively by 46. 6%, 60. 9%, 2. 6%, 37.2% and 30. 5% (all P<0, 05). The pathological damage also degraded. All these indicated that diaoxinxuekang provided significant protection on ischemic injured myocardium . The main mechanism is considered that it can prevent cell calcium overload and abate oxygen free radical injury.

关 键 词：地奥心血康 药理学 心肌损伤 

分 类 号：R965[医药卫生—药理学]