经输精管向附睾方向注射小剂量鱼肝油酸钠的抗生育效果  

THE ANTIFERTILITY EFECT INDUCED BY SMALL DOSAGE INJECTION OF SODIUM MARRHUATE TOWARD EPIDIDYMISVIA VAS DEFERENS

作　　者：张隆昌 李向安 奉孝诗 柴学国 何家碧 向代泽 王春年[2] 徐胜[2] 鲁梅格[2] 董赛珍[2] 谢文英[2] 

机构地区：[1]四川省遂宁市市中区计划生育宣传技术指导站 [2]上海第二医科大学组胚教研室

出　　处：《男性学杂志》1994年第1期20-23,共4页

摘　　要：本文报道25例经输精管向附睾方向注射0.3-0.5ml侧鱼肝油酸钠的抗生育效果及其机理探讨。在注射1～13个月后,测定精液常规,精浆中的α-1,4糖苷酶活性,肉毒碱及果糖的含量,血清中FSH、LH、PRL、T、E_2的含量。结果表明:1.糖浆中肉毒碱和α-糖苷酶含量均低于正常生育力者(p<0.001);果糖含量与正常生育力者无显著性差别(p>0.05)。2.血清中FSH、LH、PRL、T、E_2均与正常人无显著性差别(p>0.05)。3.抗生育效果:在25例中有2例女方复孕,在此术后3～4个月进行人流,以后虽然精液中仍有精子,女方均未复孕。因此,本方法可能主要是干扰附睾的功能,从而产生抗生育作用。它是一种安全、有效的男子节育方法。The antifertility effect induced by small dosage (0.3-0.5 ml/side) injection of sodium morrhuate toward epididymis via vas deferens was reported in 25 cases. The semen and blood were studied 1-13 months after treatment. The results showed : 1. The carnitine and α-glucosidase in human semen were redused (p<0.001); seminal fructose was normal (p>0.05). 2. Blood FSH, LH, PEL, testosterone and estradiol Were unchanged. 3. 3-4 months after injection, two ladies got pregnant and induced abortion. But after abortion, they were never pregnant again. Therefore, this method is a simple and nonsurgical method for male fertility control. Its mechanism on antifertility may be disturbing on the functions of epididxmis via multiple factors.

关 键 词：鱼肝油酸钠 抗生育 附睾 

分 类 号：R979.21[医药卫生—药品]