人白细胞干扰素联合中草药对乙型肝炎病人离体培养外周血淋巴细胞SCE频率的影响  

EFFECTS OF HUMAN INTERFERON-α COMBINED WITH MEDICAL HERBS ON SCE FREQUENCY IN PERIPHERAL LYMPHOCYTES FROM HEPATITIS B PATIENTS IN VITRO TREATMENT

作　　者：陈在春 王培林 丛书英[1] 韩宏志 

机构地区：[1]青岛市传染病医院,第二炮兵青岛疗养院

出　　处：《青岛医学院学报》1994年第2期87-90,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：应用人白细胞干扰素（ＨｕＩＦＮ－α）联合板蓝根注射液（ＩＲＩ）方案离体处理１６例乙型肝炎病人外周血淋巴细胞，观察病人ＳＣＥ平均频率的动力学变化。结果表明，ＨｕＩＦＮ－α联合ＩＲＩ处理实验组ＳＣＥ平均频率明显低于对照组，差异高度显著（Ｐ＜０．０１）。急性与慢性乙型肝炎实验组ＳＣＥ平均频率分别低于各自的对照组，差异也高度显著（Ｐ＜０．０１）；两者之间ＳＣＥ平均频率差异不显著（Ｐ＞０．０５）。In vitro treatment of hepa-titis B virus-infected peripheral lymphocytes from 16 hepatitis B patients with human interferon-α(HuIFN-α)combined with injectio radicis isatis(IRI),induced a decrease in the frequency of sister-chromatid exchanges(SCE),showing a significant difference(in mean SCE frequency)from the control group.There were also significant differences between patients with acute or chronic hepatitis treated with HuIFN-α combined with IRI and their respective control groups.But no difference was found between the acute and chronic hepatitis B patients treated with HuIFN-α combined with IRI.

关 键 词：干扰素 板蓝根 乙型肝炎 DSCE 淋巴细胞 

分 类 号：R512.620.3[医药卫生—内科学] R394[医药卫生—临床医学]