反相高效液相色谱法测定强力镇痛片中双氯灭痛和阿普唑仑含量  

Determination of Liclofenac and Alprazolam in QIANGLI ZHENTONG Tablets by Reverse-Phase High Performance Liquid Chromatography(RP-HPLC)

作　　者：张华安[1] 王茂义[1] 魏友侠 张广琴[1] 

机构地区：[1]西安医科大学第一附属医院药剂科,西安医科大学药学系

出　　处：《色谱》1994年第5期376-377,共2页Chinese Journal of Chromatography

摘　　要：反相高效液相色谱法测定强力镇痛片中双氯灭痛和阿普唑仑含量张华安，王茂义，魏友侠，张广琴（西安医科大学第一附属医院药剂科西安７１００６１）１前言强力镇痛片为一复方制剂，由双氯灭痛、阿普唑仑组成。由于片剂中二者含量相差悬殊（６２．５倍），用一般分析方法很...A method fOr simultaneous determination of Liclofenac and Alprazolam in QIANGLI ZHENTONGTablets by RP-HPLC was reported.Chromatographic conditions were:ODS Column as solid phase,Methanol:Water=70:30 as mobile phase, Diclofenac detected at 254nm,Alprazolam detected at 222nm,internal standard:Aminopyrine. The average recoveries of Diclofenac and Alprazolam were 101.37%(n=4)and 102. 73%(n=4)respectively. Coefficients of variation were 1.06%and 1. 73%。 The method was sim-ple,rapid and reliable.

关 键 词：镇痛片 双氯灭痛 阿普唑仑 HPLC 

分 类 号：R971.1[医药卫生—药品]