甲基黄酮醇胺对家兔主动脉条^（45）Ca跨膜流动的影响  

Effects of methylflavonolamine hydrochloride on 45Ca transmembranefluxes in rabbit aorta

作　　者：龙平 阎超华 张明升 梁月琴 周尔凤 

机构地区：[1]山西省心血管病研究所

出　　处：《山西医学院学报》1994年第4期319-322,共4页

摘　　要：本文应用４５Ｃａ流动法研究甲基黄酮醇胺（Ｍｅｔｈｙｌｌａｖｏｎｌａｍｉｎｅ，ＭＦＡ）对兔主动脉条４５Ｃａ跨膜流动的影响。发现：ＭＦＡ（０．１ｍｍｏｌ／Ｌ）时间依赖性抑制氯化钾（８０ｍｍｏｌ／Ｌ）诱导的４５Ｃａ内流及净摄取的增加，并能抑制静息状态的４５Ｃａ外流，取消并翻转去甲肾上腺素（ＮＡ，１μｍｏｌ／Ｌ）降低兔主动脉条４５Ｃａ外流作用。提示：ＭＦＡ对经ＰＤＣ的钙内流有抑制作用，并有一定的抑制钙泵及阻断α－受体作用。ffects of methylflavonolamine(MFA)on 45Ca transmembrane flu-xes were studied in rabbit aortic smooth muscle strips.MFA(0.1mmol/L)time-dependently inhibited the increase of calcium influx and net upta-ke induced by KCl(80mmol/L).Meanwhile,MFA inhibited resting 45Caefflux,and reversed the decrease of 45Ca effluX in rabbit aorta inducedby noradrenaline(NA).The results showed that MFA inhibited Ca2+influx through potential dependent Ca channel,It suggests that MFAcan inhibit calcium pump and has a bloking effect no alpha-receptor.

关 键 词：甲基黄酮醇胺 主动脉 钙跨膜流动 钙通道阻滞剂 兔 

分 类 号：R966[医药卫生—药理学] R972[医药卫生—药学]