肥大细胞与肢体淋巴水肿组织纤维化的关系  

Mast Cells and Their Relationships to Fibrosis in Lymphedematous Tissue of Lower Extremities

作　　者：苏永新[1] 张梅[1] 傅爱芬[1] 张如鸿[1] 黄文义[1] 汪铮[1] 

机构地区：[1]上海第二医科大学病理学教研室,上海第二医科大学附属第九人民医院

出　　处：《上海第二医科大学学报》1994年第2期110-114,共5页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：首次应用组织化学、生化分析和透射电镜方法，在正常对照下，对１６例下肢淋巴水肿皮肤活检组织进行了肥大细胞与局部组织胶原蛋白合成之间的相关性研究。在电镜下不仅可观察到病变组织内肥大细胞与纤维母细胞数量增多，功能活跃，肥大细胞与纤维母细胞之间在形态学上关系密切，而且还发现在原位组织内肥大细胞转颗粒现象。与正常对照组比较，淋巴水肿患肢皮肤单位面积内肥大细胞数明显增高（Ｐ＜０．００１），每ｍｍ２组织内肥大细胞数和每ｍｇ干重组织的羟脯氨酸含量变化之间呈高度相关（γ－０．９３８６４０２）。结果表明，肥大细胞是参与肢体淋巴水肿组织纤维化的重要细胞之一。The relationship between mast cell and the formation of collagen was studied in biopsies from patients with lymphedma of the lower extermities by means of histochemistry, biochemical assay of hydroxyproline and transmission electron microscope (TEM) with normal control.Histochemistry and TEM revealed that the mast cells and fibroblasts both increased in number and became more active in function in the tissue affected with lymphedema. A close interrelationship could traced between the 2 types of cells, and also between the number of mast cells per square mm and the weight of hyderxyproline per mg of dry tissue (r=0.9386402).The results indicated that the mast cell played an important role in the formation of fibrosis in lymphedematous tissue.

关 键 词：淋巴水肿 肥大细胞 纤维化 

分 类 号：R551.2[医药卫生—血液循环系统疾病]