开玛条件下氨茶碱降压作用量效关系的研究  

A Quantitative Dose-effect Relationship Study of the Hypotensive Action of Aminophylline under CAIMA

作　　者：丁洪流[1] 谢国斌[1] 王载礼[1] 金正均[1] 

机构地区：[1]上海第二医科大学药理学教研室

出　　处：《上海第二医科大学学报》1994年第3期206-209,共4页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：本文研究了开玛条件下氨茶碱量效关系的特点。实验结果显示：１．开玛与非开玛条件下量效关系不同，开玛量效曲线左移，以中段最为显著。２．开玛条件下效应恒定时血药浓度相对稳定，而维持用药量呈不规则变化。３．开玛条件下血药浓度与效应以及用药量与效应均有相关性。A CAMIA model of aminophylline hypotensive action was developed.The concentration-effect and dose-effcet curves were discribed with a non-CAIMA model served as control.The changes of dose and concentration in steady effect state were also investigated. Results led to the following conclusions:(1) Some differences were found in the concentration-effect and dose-effect curves between CAIMA and non-CAIMA. Curves under CAIMA underwent a left-ward shift with their middle part affected most.(2) When the effect was constant under CAIMA, the concentration remained stable while the dosage of drug required varied.(3) Under CAIMA, the concentration-and dose-effect showed a quantitative relationship.

关 键 词：开玛给药系统 氨茶碱 血药浓度 降压药 

分 类 号：R972.4[医药卫生—药品]