卡介菌多糖核酸对T细胞集落形成及IL－2受体表达的调节作用  

REGULATORY EFFECTS OF BCG-PSN ON T CELL COLONY FORMATION AND EXPRESSION OF INTERLEUKIN-2 RECEPTOR

作　　者：金一平[1] 方建珍[1] 高洁生[1] 

机构地区：[1]湖南医科大学第二附属医院

出　　处：《上海免疫学杂志》1994年第1期5-8,共4页Shanghai Journal of Immunology

基　　金：CMB基金

摘　　要：本文用体外实验方法，研究ＢＣＧ－ＰＳＮ对ＴＬ－ＣＦｕ形成及ＩＬ－２Ｒ表达的调节作用。结果表明，当ＢＣＧ－ＰＳＮ浓度为８０μｇ／ｍｌ时，ＴＬ－ＣＦＵ形成及ＩＬ－２Ｒ表达均达到峰值，对ＩＬ－２Ｒ表达的调节于７２ｈ达最高水平，并且．ＴＬ－ＣＦＵ形成和ＩＬ－２Ｒ表达均显著高于对照组。提示ＢＣＧ－ＰＳＮ能增进Ｔ淋巴细胞功能。The immunoregulatory action of polysaccharide-nucleic acid fraction fromBacillus-Calmatte-Guerin(BCG-PSN)on T-cell colony forming units(TL-CFU)andInterleukine 2 receptor(IL-2R)expression were studied in vitro. The results showedthat the number of TL-CFU and IL-2R positive cells were significantly higher inBCG-PSN activated group than those in controls.This suggested that BCG-PSN couldpromote T lymphocyte function and increase the cellular immunity.

关 键 词：卡介菌 多糖核酸 免疫调节 T细胞 

分 类 号：R979.5[医药卫生—药品]