联合应用乙肝疫苗和HBIG阻断母婴传播效果观察  

STUDIES ON BLOCKING OF MOTHER-TO-INFANT TRANSMISSION OF HEPATITIS B INFECTION USING VACCINE COMBINED WITH IMMUNE GLOBULIN(HBIG)

作　　者：李雪翔[1] 叶和清[1] 罗金凤 杜玉霞 史鉴 肖亮明[1] 姚福宝 谢广钟[1] 章濬 石厚昌 蒋前锋 王兰芳 

机构地区：[1]卫生部上海生物制品研究所,徐州医学院附属医院,扬州医学院苏北人民医院,扬州市卫生防疫站,上海市纺织管理局第二医院,上海市闸北区妇幼保健院

出　　处：《上海免疫学杂志》1994年第2期85-88,共4页Shanghai Journal of Immunology

摘　　要：母亲ＨＢｓＡｇ和ＨＢｅＡｇ均阳性者所生婴儿为观察对象。分１０μｇ×３、２０μｇ×３和３０μｇ×３三组，每组又分联合组（乙肝疫苗加ＨＢＩＧ）和单苗组（单用乙肝疫苗），按０、１、６月程序肌内注射。２０μｇ和３０μｇ两组１２月龄时联合组和单苗组ＨＢｓＡｇ阳性率差别无显著性，但联合组抗－ＨＢｓ阳性率和ＧＭＴ均较单苗组为高。１０μｇ×３联合组１２月龄时ＨＢｓＡｓ感染率和３０μｇ×３单苗组相仿，用此法免疫，价格低廉，建议采用。Infants born to women both HBsAg and HBeAg positive were divided into threegroups receiving different doses of HB vaccine at birth, one and six months (10μg×3,20μg×3 and 30μg×3). Each group was further divided into combined (vaccine plus200IU HBIG once at birth)and vaeoine alone subgroups. At 12 months,the HBsAgpositive rates in all these subgroups were not significantly different.RBsAg positiverate was about the same in 10μg×3 combined subgroup and 30pg x 3 vaceine alonesubgroup. However, the former regimen cost much ies,hence being the preferablemothod.

关 键 词：乙型肝炎疫苗 免疫球蛋白 联合免疫 

分 类 号：R512.620.3[医药卫生—内科学]