婴儿肝炎综合征的临床与病理观察  

CLINICAL AND PATHOLOGICAL OBSERVATION ON HEPATITIS SYNDROME IN INFANCY

作　　者：宋学枋[1] 王岱明[1] 朱畅宁[1] 顾静安[1] 

机构地区：[1]上海医科大学儿科医院传染病科

出　　处：《上海医科大学学报》1994年第3期212-215,共4页Journal of Fudan University(Medical Science)

摘　　要：报道我院１４年来诊断为婴儿肝炎综合征（婴肝）住院并死亡的５１例病儿。为探讨婴肝患者的肝脏病理改变与死亡的关系，我们对全部病儿进行尸检，并根据肝脏病理变化分以下几型：①重症肝炎：（急性及亚急性）２８例（５４．９０％）；②急性肝炎：９例（１７．６５％）；③巨细胞病毒肝炎（ＣＭＶ）：３例（５．８８％）；④慢性活动性肝炎（ＣＡＨ）：２例（３．９２％）；⑤胆道闭锁及胆汁性肝硬变：９例（１７．６５％）。根据上述病理改变明确了婴肝患儿肝脏病变的病因，与国内１９９１年林氏报道相比，更多了ＣＭＶ及ＣＡＨ两型病变，对临床为降低婴肝病死率，在诊治该类病儿时具进一步的参考及指导意义。This article is to report the pathological findings of infantile hepatitis syndrome obtained from autopsy during the period of Jan. 1975～Dec.1988.The mortality rate was 7.12%,accounting for 4.3% of the total autopsies during the same period.Of all the 51 cases,31 were males and 20-females.45 of them were under the age of 6 months,accounting for 88.3%.According to the pathological changes of the liver,the pathological findings may be classified as follows:1.Fulminant hepatitis,acute or subacute: 28 cases,accounting for 54.90%.2.Acute hepatitis:9 cases,17.65%.3.Cytomegaloviral hepatitis:3 cases,5.85%.4.Chronic active hepatitis:2 cases,3.92%.5.Biliary atresia and biliary cirrhosis:9 cases,accounting for 17.65%.47 cases in this group had clinical complications,accounting for 92.16%.Most of the complications were pneumonia and septicemia.In the process of autopsy,pneumonia was found in 44 cases,accounting for 86.12%,13 of them had pulmonary hemorrhage.19 of them had changes in thymus,accounting for 37.25%.3 cases were found to have the viscerl fungi infection.Although 40 of the 51 cases died of their primary disease,the various complicatinos were also an important cause of death.

关 键 词：婴儿 肝炎综合征 尸体解剖 病理 

分 类 号：R725.751[医药卫生—儿科]